2024
- Adams P, Thies JL, Sutton JM, Millwood JD, Caldwell GA, Caldwell KA, Fierst JL (2024) Identifying transgene insertions in Caenorhabditis elegans genomes with Oxford Nanopore sequencing. Peer J. doi: 10.7717/peerj.18100
- Muñoz A, Benseny-Cases N, Guha S, Barba 1st, Caldwell KA, Caldwell GA, Agulló L, Yuste VJ, Laromaine A, Dalfó E. (2024) Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson's disease. Prog Neurobiol. 20:102572. doi: 10.1016/j.pneurobio.2024.102572.
- Balasubramaniam M, Narasimhappagari J, Liu L, Ganne A, Ayyadevara S, Atluri R, Ayyadevara H, Caldwell G, Reis RJS, Barger SW, Griffin WST (2024). Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules. Commun. Biol. 8;7(1):60. doi: 10.1038/s42003-024-05767-9.
- Mack, K*, Kim H*, Barbieri EM, Lin J, Braganza S, Jackrel ME, DeNizio JE, Yan X, Chuang E, Tariq A, Cupo RR, Castellano LM, Caldwell KA, Caldwell GA**, Shorter J** (2023) Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell. S1097-2765(23)00604-4. doi: 10.1016/j.molcel.2023.07.029. [*co-first author; **co-corresponding author]
- Caldwell, GA (2023) Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model. Dis. Model. Mech., 16:dmm050333.
- Gaeta AL, Willicott K, Willicott CW, McKay LE, Keogh, CM, Altman, TJ, Kimble LC, Yarbrough AL, Berkowitz, LA, Caldwell, KA, Caldwell, GA (2023) Mechanistic Impacts of Bacterial Diet on Dopaminergic Neurodegeneration in a C. elegans α-synuclein Model of Parkinson’s Disease. iScience, 26:106859 doi.org/10.1016/j.isci. 2023.106859.
- Starr, LA, McKay, LE, Peter, KN, Seyfarth, LM, Berkowtiz, LA, Caldwell, KA, Caldwell GA (2023). Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2. J. Devel. Biol. 11:20 https://doi.org/10.3390/jdb11020020.
- Thies JL, Willicott K, Craig ML, Greene MR, DuGay CN, Caldwell GA, Caldwell KA. (2023) Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans. Cells. 12:1170. https://doi.org/10.3390/cells12081170.
- Schlein ML, Arituluk ZC, Stephen CA, Caldwell GA, Ciesla L, Caldwell KA. (2023). A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts. Micropub. Biol. 2023:10.17912/micropub.biology.000780. doi:10.17912/micropub.biology.000780.
- Nourse JB Jr, Russell SN, Moniz NA, Peter K, Seyfarth LM, Scott M, Park HA, Caldwell KA, Caldwell GA (2023) Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models. Proc Natl. Acad. Sci. USA. 120:e2210712120. https://doi.org/10.1073/pnas.2210712120.
- Mew M, Caldwell KA, Caldwell GA. (2022) From Bugs to Bedside: functional annotation of human genetic variation for neurological diseases using invertebrate models. Human Mol. Genet. 31, R37-R46. https://doi.org/10.1093/hmg/ddac203
- Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, Caldwell KA, Selkoe D. (2022) Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. NPJ Nature Parkinson's Dis. 8:74. doi: 10.1038/s41531-022-00335-6.
- Gaeta AL, Nourse JB Jr., Willicott K, McKay LE, Keogh CM, Peter K, Russell SN, Hamamichi S, Berkowitz LA, Caldwell KA, Caldwell GA. (2022) Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. PLoS Genetics. 18: e1010115. doi:10.1371/journal.pgen.1010115
- Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA, Shen HM, Nilsen H, Lu JH, Fang EF. (2022) Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nature Biomedical Eng. 6:76-93. doi: 10.1038/s41551-021-00819-5.
- van der Welle REN, Jobling R, Burns C, Sanza P, van der Beek JA, Fasano A, Chen L, Zwartkruis FJ, Zwakenberg S, Griffin EF, Ten Brink C, Veenendaal T, Liv N, van Ravenswaaij-Arts CMA, Lemmink HH, Pfundt R, Blaser S, Sepulveda C, Lozano AM, Yoon G, Santiago-Sim T, Asensio CS, Caldwell GA, Caldwell KA, Chitayat D, Klumperman J. (2021) Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation. EMBO Molecular Medicine. 13:e13258. doi: 10.15252/emmm.202013258.
- Nourse JB Jr, Harshefi G, Marom A, Karmi A, Cohen Ben-Ami H, Caldwell KA, Caldwell GA, Treinin M. Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress. (2021) iScience, 24:102140, doi:10.1016/j.isci.2021.102140
- McGrath K, Agarwal S, Tonelli M, Dergai M, Gaeta AL, Shum AK, Lacoste J, Zhang Y, Wen W, Chung D, Wiersum G, Shevade A, Zaichick S, van Rossum DB, Shuvalova L, Savas JN, Kuchen S, Taipale M, Caldwell KA, Caldwell GA, Fasshauer D, Caraveo G. (2021) A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6. Proc. Natl. Acad. Sci. USA. 118:e2016730118 doi:10.1073/pnas.2016730118
- Klionsky et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 17:1-382. doi: 10.1080/15548627.2020.1797280.
- March ZM, Sweeney K, Kim H, Yan X, Castellano LM, Jackrel ME, Lin J, Chuang E, Gomes E, Willicott CW, Michalska K, Jedrzejczak RP, Joachimiak A, Caldwell KA, Caldwell GA, Shalem O, Shorter J. (2020) Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife. 9:e57457, doi: 10.7554/eLife.57457
- Caldwell KA, Willicott CW, Caldwell GA. (2020) Modeling neurodegeneration in Caenorhabditis elegans. Disease Models and Mechanisms, 13:dmm046110. doi: 10.1242/dmm.046110.
- Vaji MA, Caldwell GA, Caldwell KA. (2020) Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM encephalopathy. MicroPubl Biol. 2020 doi:10.17912/micropub.biology.000296
- Vaji MA, Caldwell GA, Caldwell KA (2020) Phenotypic modulation of pentylenetetrazole-induced convulsive behaviors in C. elegans carrying a mutation associated with Alzheimer's disease. MicroPubl Biol. 2020: doi:10.17912/micropub.biology.000295
- Hartman JH, Gonzalez-Hunt C, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN (2019) Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration. Int J Mol Sci. 20, pii: E3202. doi: 10.3390/ijms20133202
- Gaeta AL, Caldwell KA, Caldwell, GA (2019) Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's disease. Brain Sciences, 9, 73; doi:10.3390/brainsci9040073.
- Griffin EF, Scopel SE, Stephen CA, Holzhauer AC, Vaji MA, Tuckey, RA, Berkowitz LA, Caldwell KA, Caldwell GA (2019) ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans. Disease Models and Mechanisms, 12, dmm037218. doi:10.1242/dmm.037218.
- Griffin EF, Caldwell, KA, Caldwell GA (2019) Vps41 at the intersection of endosomal traffic in neurodegenerative disease. Neural Regeneration Research, 14 (7):1210-1212. doi: 10.4103/1673-5374.251329.
- Daniels MJ, J Brucker Nourse Jr, Kim H, Schiavina M, Sainati V, Murrali MG, Pan B, Ferrie JJ, Haney CM, Moons R, Gould NS, Natalello A, Grandori R, Sobott F, Petersson EJ, Rhoades E, Pierattelli R, Felli I, Uversky VN, Caldwell KA, Caldwell GA, Krol E, Ischiropoulos H. (2019) Cyclized NDGA modifies dynamic alpha-synuclein monomers preventing aggregation and toxicity. Scientific Reports, 9:2937 | doi.org/10.1038/s41598-019-39480-z
- Caldwell KA, Thies JL, Caldwell GA (2018) No Country for Old Worms: A systematic review of the application of C. elegans to investigate a bacterial source of environmental neurotoxicity in Parkinson's disease. Metabolites 8:E70. doi: 10.3390/metabo8040070.
- Griffin EF, Yan X, Caldwell KA, Caldwell GA (2018) Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration. Human Molecular Genetics doi.org/10.1093/hmg/ddy308
- Kim H, Perentis RJ, Caldwell GA, Caldwell KA (2018) Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson’s models. Cell Death Disease. doi/org/10.1038/s41419-018-0619-5
- Patel D, Xu C, Nagaragjan S, Liu Z, Hemphill WO, Shi R, Uversky VN, Caldwell GA, Caldwell KA, Witt SN. (2018) Alpha-synuclein inhibits Snx-3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. Human Molecular Genetics. 27:1514–1532. doi.org/10.1093/hmg/ddy059
- Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago, Kapahi P, Raya A, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E. (2018) The small GTPas RAC1/CED-10 is essential in maintaining dopaminergic neuron function and survival against α-synuclein-induce toxicity. Molecular Neurobiology doi.org/10.1007/s12035-018-0881-7
- Martinez BA, Petersen DA, Gaeta AL, Stanley SP, Caldwell GA, Caldwell KA. (2017) Dysregulation of the mitochondrial unfolded protein response induces non-apoptotic dopaminergic neurodegeneration in C. elegans models of Parkinson's disease. J Neurosci. doi:10.1523/JNEUROSCI
- Griffin EF, Caldwell KA, Caldwell GA. (2017) Genetic and pharmacological discovery for Alzheimer's Disease using C. elegans. ACS Chem Neurosci. doi: 10.1021/acschemneuro.7b00361
- Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. (2017) Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem. Neurosci. doi: 10.1021/acschemneuro.7b00187
- Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiopoulos H. (2017) Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature Neuroscience. doi:10.1038/nn.4641
- Zhang S, Glukhova SA, Caldwell KA, Caldwell GA. (2017) NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease. Human Molecular Genetics. 26:3823–3836.
- Martinez BA, Caldwell KA, Caldwell GA. (2017) C. elegans as a model system to accelerate discovery for Parkinson disease. Current Opinion in Genetics & Development. 44:102-109
- Wang S, Zhang S, Xu C, Barron A, Galiano F, Patel D, Lee YJ, Caldwell GA, Caldwell KA, Witt SN. (2016) Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease. PLoS One. 11(10):e0164465
- Watkins AL, Ray A, R Roberts L, Caldwell KA, Olson JB. (2016) The prevalence and distribution of neurodegenerative compound-producing soil Streptomyces spp. Scientific Reports. 6:srep22566
- Martinez BA, Kim H, Ray A, Caldwell GA, Caldwell KA. (2015) A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans . Cell Death Disease. 6:e1908
- Ray A, Rentas C, Caldwell GA, Caldwell KA. (2015) Phenazines cause proteotoxicity and stress in C. elegans. Neurosci Lett. 584:23-27
- Johnson WM, Yao C, Siedlak S, Wang W, Zhu X, Caldwell GA, Wilson-Delfosse AL, Mieyal JJ, and Chen S. (2014) Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson’s disease. Hum Mol Genet. 24(5):1322-35
- Ray A, Zhang S, Rentas C, Caldwell KA, Caldwell GA. (2014) RTCB-1 Mediates Neuroprotection via XBP-1 mRNA Splicing in the Unfolded Protein Response Pathway. J Neurosci. 34:16076–16085
- Caldwell GA and Caldwell KA. Use of C. elegans to Model Human Movement Disorders. (2014) In "Movement Disorders, 2nd Ed."(LeDoux, MS, ed.). New York: Elsevier. pp. 98-112
- Wang S, Zhang S, Liou L-C, Ren Q, Zhang Z, Caldwell GA, Caldwell KA, and Witt, SN. (2014) Phosphatidylethanolamine deficiency enhances α-synuclein toxicity in yeast and worm models of Parkinson's disease. Proc Natl Acad Sci USA. 111:E3976–E3985
- Caraveo G, Auluck PK, Whitesell L, Chung C-Y, Baru V, Mosharov E, Yan X, Ben Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer DA, Yue DT, Lindquist S. (2014) Calcineurin determines toxic versus beneficial responses to α-synuclein. Proc Natl Acad Sci USA. 111:E3544-52
- Knight AL, Yan X, Hamamichi S, Aijuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, Caldwell KA, Caldwell GA (2014) The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson's Models. Cell Metab. 20(1):145-57
- Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S (2014) Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci USA .111(11):4013-8
- Bornhorst J, Chakraborty S, Meyer S, Lohren H, Große Brinkhaus S, Knight AL, Caldwell KA,Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M.(2014) The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.. Metallomics . 6(3):476-90
- Thompson ML, Chen P, Yan X, Kim H, Borom AR, Roberts NB, Caldwell KA, Caldwell GA.(2014) TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.. Disease Models and Mechanisms. 7(2):233-43
- Munoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Szewczyk NJ, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A.(2014) Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases. Antioxidants Redox Signaling. 20:217-35
- Ray A, Martinez BA, Berkowitz LA, Caldwell GA, Caldwell KA.(2014) Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson’s model. Cell Death Disease. 5:e984
- Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J.(2014) Potentiated HSP104 Variants ANtagonize Diverse Proteotoxic Misfolding Events. Cell . 156:170-182
- Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet J-C, Buchwald SL, Lindquist S.(2013) Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates α-synuclein Toxicity in Neurons. Science . 342:979-83
- Caldwell KA, Shu Y, Roberts NB, Caldwell GA, O'Donnell JM.(2013) Invertebrate Models of Dystonia. Curr Neuropharm. 11:16-29
- Kautu BB, Carrasquilla A, Hicks ML, Caldwell KA, Caldwell GA.(2013) Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling. Neurosci Lett. 541:116-9
- Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Lein C, Vila M, Bezard E.(2013) Lysosomal impairment in Parkinson's disease. Mov Disord. 28(6):725-32
- Usenovic, M., Knight, A.L., Ray, A., Wong, V., Brown, K.R., Caldwell, G. A., Caldwell, K.A., Stagljar, I., and Krainc, D.(2012)Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. Human Molecular Genetics.17:3785-3794
- Dexter, P.M., Caldwell, K.A., and Caldwell, G.A. (2012) A Predictable Worm: Application of C. elegans to Mechanistic Investigation of Movement Disorders. Neurotherapeutics 9(2):393:404.
- Harrington, A.J., Yacoubian, T.A., Sloan, S.R, Caldwell, K.A., and Caldwell, G.A. (2012) Functional analysis of VPS41-mediated neuroprotection in C. elegans and mammalian models of Parkinson’s disease. J. Neurosci., 32:2142-2153.
- Tardiff, D.F, Tucci, M.L. Caldwell, K.A., Caldwell, G.A., and Lindquist S. (2012) Different 8-hyroxyquinolines protect models of TDP-43, a-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J. Biol. Chem. 287:4107-2120.
- Caldwell K.A. and Caldwell, G.A. (2011). Methodological strategies to evaluate functional effectors related to Parkinson’s disease through application of C. elegans models In Contemporary Animal Models of Movement Disorders: Methods and Protocols (Lane E. and Dunnett, S., eds.). Humana Press
- Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, Dejager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S. (2011) Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast. Science 334(6060):1241-1245.
- Mazzulli, JR, Xu Y-H, Sun Y, Knight AL, McLean PJ, Caldwell GA, Grabowski GA, Krainc D (2011). Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell, 146:37-52.
- Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PL, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS (2011).Structural Features and Chaperone Activity of the NudC Protein Family J Mol Biol. 409:722-741.
- Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson, VL (2011) Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum. Mol. Genet., 20:3933-42.
- Tucci, ML, Harrington, AJ, Caldwell, GA, Caldwell KA (2011) Modeling dopamine neuron degeneration in C. elegans.Methods in Molecular Biology., (Kawamata, H. and Manfredi, G.M., eds.) Humana Press.
- Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, daHora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO (2011) TorsinA participates in endoplasmic reticulum-associated degradation (ERAD). Nature Comm 12;2:393.
- Harrington AJ, Knight AL, Caldwell GA, Caldwell KA (2011) C. elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson’s disease. Methods, 53:220-225.
- Caldwell GA, Caldwell KA (2010) Disinfecting dystonia? Drug discovery using worms identifies an antibiotic as a neuroprotective lead molecule for movement disorders.. Future Neurol. 5:473-476.
- Tucci ML, Caldwell GA, Caldwell KA. (2010) Cell culture to investigate neurotoxicity and neurodegeneration utilizing Caenorhabdidits elegans. In Cell Culture Techniques: Neuromethods. Aschner M.
- Chen P*, Burdette AJ*, Porter JC, Ricketts JC, Fox SA, Nery FC, Hewett JW, Breakefield XO, Caldwell KA, Caldwell GA. (2010) The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. . Hum. Mol. Genet. 19:3502-3515.
- Pivtoraiko VN, Harrington AJ, Mader BJ, Luker AM, Caldwell GA, Caldwell KA, Roth KA, Shacka JJ. (2010) Low-dose bafilomycin attenuates neuronal cell death associated with autophagic-lysosome pathway dysfunction.. J. Neurochem. 114:1193-1204.
- Cao S, Hewett JW, Yokoi F, Lu F, Buckley AC, Burdette AJ, Chen P, Nery FC, Li Y, Breakefield XO, Caldwell GA, Caldwell KA. (2010)Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. . Dis. Model. Mech. 3:386-396.
- Burdette AJ, Churchill PF, Caldwell GA, Caldwell KA. (2010) The early-onset torsion dystonia protein, torsinA, displays molecular chaperone activity in vitro. . Cell Stress and Chaperones 15:605-617.
- Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA. (2010) C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.. Dev. Dyn. 239:1282-1295.
- Yacoubian TA, Sloan SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG. (2010) Differential neuroprotective effects of 14-3-3 in models of Parkinson's disease.. Cell Death Dis. 1 :e2; doi:10.1038/cddis.2009.4
- Su J, Auluck PK, Outerio TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet J-C, Lindquist S. (2010) Compounds from an unbiased chemical screen reverse both ER-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.. Dis. Model. Mech.37:330-338.
- Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG. (2010) VPS41, a protein involved in lysosomal trafficking, is protective in mammalian cellular models of Parkinson's disease.. Neurobiol. Dis. 37:330-338.
- Locke CJ*, Kautu BB*, Berry KP, Lee SK, Caldwell KA, Caldwell GA. (2009) Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in C. elegans GABAergic neurotransmission.. Genetics 183:1357-1372.
- Caldwell KA, Tucci ML, Armagost J, Hodges TW, Chen J, Memon SB, Blalock JE, DeLeon SM, Findlay RF, Ruan Q, Webber PJ, Standaert DG, Olson JB, Caldwell GA. (2009) Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.. PLoS ONE. 4:e7227.
- Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S. (2009) Rapid selection of cyclic peptide that reduce alpha-synuclein toxicity in yeast and animal models.. Nature Chemical Biology. 5:655-663.
- Locke CJ, Caldwell KA, Caldwell GA. (2009) The nematode, C. elegans, as an emerging model of seizures and epilepsy.. In Animal Models of Epilepsy: Methods and Innovations Neuromethods. Baraban SC (ed.) Humana Press, Totowa, NJ. 40:1-25.
- Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet J-C, Lindquist S. (2009) a-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity..Nature Genetics. 41:308-315.
- Faircloth LM, Churchill PF, Caldwell GA, Caldwell KA. (2009) The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro.. Cell Stress and Chaperones. 14:95-103.
- Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Wilson S, Yacoubian TA, Xie Z-L, Speake LD, Parks R, Crabtree D, Crimmins S, Uchiyama Y, Zhou Y, Peng L, Lu Y, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J. (2008) A neuroprotective role of lysosomal enzyme cathepsin D against alpha-synuclein pathogenesis.. Mol. Brain 1:17
- Caldwell GA, Caldwell KA. (2008) Traversing a wormhole to combat Parkinson's disease.. Disease Models Mech. 1:32-36
- Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA. (2008) Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.. J Vis Exp. Jul 18;(17). pii: 835. doi: 10.3791/835
- Berkowitz LA, Knight AL, Caldwell GA, Caldwell KA. (2008) Generation of stable transgenic C. elegans using microinjection.. J Vis Exp. Aug 15;(18). pii: 833. doi: 10.3791/833
- Locke C, Berry K, Kautu B, Lee K, Caldwell K, Caldwell G. (2008) Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants.. J Vis Exp. Aug 15;(18). pii: 837. doi: 10.3791/837
- Locke CJ, Fox SA, Caldwell GA, Caldwell KA. (2008) Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.. Neurosci Lett. 439:129-33
- Jinnah HA, Richter A, Mink JW, Caldwell GA, Caldwell KA, Gonzalez-Alegre, P, Cookson MR, Breakefield XO, DeLong MR, Hess EJ.(2013) Animal Models for Drug Discovery in Dystonia. In Expert Opinion in Drug Discovery 3:83-97.
- Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA. (2008) Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.. Proc Natl Acad Sci USA 105:728-33
- Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. (2008) The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.. Proc Natl Acad Sci USA105:145-50.
- Howard RA, Sharma P, Hajjar C, Caldwell KA, Caldwell GA, du Breuil R, Moore R, Boyd L. (2007) Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.. BMC Cell Biol 8:32
- Locke CJ, Williams SN, Schwarz EM, Caldwell GA, Caldwell KA. (2006) Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.. Brain Research 1120:23-34.
- Caldwell GA, Williams SN, Caldwell KA. (2006) Integrated Genomics: A Discovery-Based Laboratory Course.. Chichester, England (John Wiley & Sons publishers). Textbook. Amazon link
- Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Kolodner RD, Marsischky G, LaBaer J, Rochet J-C, Bonini NM, Lindquist S. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 Rescues Neuron Loss in Parkinson's Models.. Science 313:324-328
- Dickey CA, Yue M, Lin W-L, Dickson DW, Dunmore JH, Wing C, Lee CZ, West G, Cao S, Clark AMK, Caldwell KA, Caldwell GA, Eckman C, Patterson C, Hutton M, Petrucelli L. (2006) Deletion of the ubiquitin ligase, CHIP, leads to accumulation, but not aggregation, of both endogenous phospho- and caspase-3 cleaved tau species.. J. Neurosci. 26:6985-6996
- Cao S, Gelwix CC, Caldwell KA, Caldwell GA. (2005) Torsin-mediated protection from Cellular Stress in the Dopaminergic Neurons of Caenhorhabditis elegans.. J. Neurosci. 25:3801-3812
- Locke CJ, Caldwell KA, Caldwell GA. (2005) CarpeDB: A comprehensive database on the genetics of epilepsy.. Nucleic Acids Res.33:D5-24
- Caldwell GA, Cao S, Izevbaye I, Caldwell KA. (2005) Use of C. elegans to Model Human Movement Disorders.. In Animal Models of Movement Disorders (LeDoux, M., ed.) Elsevier, New York, pp. 111-126
- Caldwell GA, Cao S, Gelwix CC, Sexton EG, Caldwell KA. (2004) An Animal Model to Discern Torsin Function: Suppression of Protein Aggregation in C. elegans.. Adv. Neurol. 94:79-85
- Zhang S, Keller CA, Yao CA, Caldwell GA, Chalfie M. (2004) MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain.. Curr. Biol. 14:1888-1896
- Williams SN, Locke CJ, Braden AL, Caldwell KA, Caldwell GA. (2004) Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in C. elegans.. Hum. Mol. Genet. 13:2043-2059
- Swatloski RP, Rogers RD, Holbrey JD, Turner MB, Memon SB, Caldwell GA, Caldwell KA. (2004) Using Caenorhabditis elegans to Probe Toxicity of 1-alkyl-3-methylimidazolium Chloride Based Ionic Liquids. href="pdf/chemcomm.pdf">. Chem. Comm. 6:689-690
- Aumais JP, Williams, SN, Luo W, Nishino M, Caldwell, KA, Caldwell, GA, Lin S-H, Yu-Lee L. (2003) A Role for NudC, a Dynein-Associated Nuclear Movement Protein, in Mitosis and Cytokinesis.. J. Cell Sci. 116:1991-2003
- Caldwell GA, Cao S, Sexton EG, Gelwix CC, Bevel JP, Caldwell KA. (2003) Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins.. Hum. Mol. Genet. 12(3):307-319. Cover story
- Caldwell GA. (2003) As the Worm Turns: Discovering a Life of Discovery. The Washington & Lee Journal of Science 4:41-44
- Dawe AL, Caldwell KA, Harris PM, Morris NR, Caldwell GA. (2001) Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dev. Genes Evol. 211:434-441.